Optimizing diastolic pressure gradient assessment

Assessment of diastolic function using myocardial velocity gradient.

Assessment of renal artery stenosis severity by pressure gradient measurements.

OBJECTIVES The purpose of this study was to define "significant" renal artery stenosis (i.e., a stenosis able to induce arterial hypertension). BACKGROUND The degree of renal artery stenosis that justifies an attempt at revascularization is unknown. METHODS In 15 patients, transstenotic pressure measurements were obtained before and after unilateral stenting. After stenting, graded stenoses...

Noninvasive assessment of the right ventricular filling pressure gradient.

BACKGROUND The physiological basis of right ventricular (RV) diastolic function remains incompletely studied in humans. The driving force responsible for RV filling, the pressure gradient along the RV inlet from the right atrium to the RV apex, has never been measured in the clinical setting. METHODS AND RESULTS We validated a method for measuring the RV filling pressure difference (RVFPD) fr...

Assessment of the transvalvular pressure gradient in aortic stenosis.

Characterization of Pulmonary Hypertension in Heart Failure Using the Diastolic Pressure Gradient

We read with interest the paper by Tampakakis et al. (1) and accompanying editorial by Chatterjee and Lewis (2) in a recent issue of JACC: Heart Failure refuting the prognostic value of the diastolic pulmonary gradient (DPG) (3). In addition to numerous limitations that are acknowledged both in the original paper and the editorial, it is important to point out details regarding the prognostic r...